Kodi pali ubale wotani pakati pa kukhumudwa muzaka zapakati ndi kukhazikitsidwa kwa Tau?

Malinga ndi kafukufuku watsopano wa ofufuza a UT Health San Antonio ndi mabungwe omwe amawathandiza, anthu azaka zapakati omwe ali ndi zizindikiro zowawa amanyamula mapuloteni otchedwa APOE.Kusintha kwa epsilon 4 Kutha kukhala kothekera kutulutsa tau buildup m'malo aubongo omwe amawongolera malingaliro ndi kukumbukira.

news-3

Zotsatirazo zidasindikizidwa mu kope losindikizidwa la June 2021 la Journal of Alzheimer's Disease.Phunziroli linakhazikitsidwa pa kuwunika kwa kupsinjika maganizo ndi kulingalira kwa positron emission tomography (PET) kwa otenga nawo gawo 201 mu Multigenerational Framingham Heart Study.Avereji ya zaka za omwe adatenga nawo mbali inali 53.

Mwayi wopeza matendawa zaka makumi ambiri asanazindikire

PET nthawi zambiri imachitika mwa okalamba, kotero kuti Framingham STUDY pa PET m'zaka zapakati ndi yapadera, adatero Mitzi M. Gonzales, wolemba wamkulu wa phunziroli ndi neuropsychologist ku Glenn Biggs Institute for Alzheimer's disease and Neurodegenerative Diseases, yomwe ili mbali ya University of Texas Health Center ku SAN Antonio.

"Izi zimatipatsa mwayi wosangalatsa wophunzirira anthu azaka zapakati ndikumvetsetsa zinthu zomwe zingagwirizane ndi kudzikundikira kwa mapuloteni mwa anthu omwe ali ndi chidziwitso," adatero Dr. Gonzales."Ngati anthuwa apitiliza kudwala matenda a dementia, kafukufukuyu avumbulutsa zotheka zaka makumi ambiri asanazindikire."

Palibe chochita ndi beta-amyloid

Beta-amyloid (Aβ) ndi Tau ndi mapuloteni omwe amaunjikana muubongo wa anthu omwe ali ndi matenda a Alzheimer's ndipo nthawi zambiri amawonjezeka pang'onopang'ono akamakalamba.Kafukufukuyu sanapeze mgwirizano pakati pa zizindikiro za kukhumudwa ndi kukhumudwa ndi beta-amyloid.Zinangolumikizidwa ndi Tau, komanso zonyamula za APOE ε4 mutation.Pafupifupi kotala la odwala 201 (47) adanyamula jini ya ε4 chifukwa anali ndi ε4 allele imodzi.

Kunyamula jini imodzi ya APOEε4 kumawonjezera chiopsezo cha matenda a Alzheimer kawiri kapena katatu, koma anthu ena omwe ali ndi mitundu yosiyanasiyana ya majini amatha kukhala ndi moyo mpaka zaka za 80 kapena 90 popanda kudwala matendawa."Ndikofunika kukumbukira kuti chifukwa chakuti munthu amadziwika kuti wanyamula APOE ε4 sizikutanthauza kuti adzakhala ndi dementia m'tsogolomu," adatero Dr. Gonzales.Zimangotanthauza kuti chiwopsezo chakwera kwambiri. "

Zizindikiro za kuvutika maganizo (kuvutika maganizo ngati zizindikiro zimakhala zovuta kwambiri kuti zithetse vutoli) zinayesedwa panthawi ya kujambula kwa PET ndi zaka zisanu ndi zitatu zisanayambe kugwiritsa ntchito Epidemiological Research Center Depression Scale.Zizindikiro za kupsinjika maganizo ndi mgwirizano pakati pa kuvutika maganizo ndi zotsatira za PET pa nthawi ziwiri zinayesedwa, kusinthidwa kwa zaka ndi jenda.

Malo okhudza maganizo ndi chidziwitso

Kafukufukuyu adawonetsa kugwirizana pakati pa zizindikiro za kupsinjika maganizo ndi kuwonjezeka kwa tau m'madera awiri a ubongo, entorhinal cortex ndi amygdala."Mayanjano awa sakutanthauza kuti kudzikundikira tau kumayambitsa matenda ovutika maganizo kapena mosemphanitsa," adatero Dr. Gonzales."Tinangowona zinthu ziwirizi mu ε4 zonyamulira."

Adanenanso kuti entorhinal cortex ndiyofunikira pakuphatikiza kukumbukira ndipo imakhala malo omwe kuyika kwa mapuloteni kumachitika msanga.Panthawiyi, amygdala amaganiziridwa kuti ndi malo okhudzidwa ndi ubongo.

"Maphunziro aatali amafunikira kuti apitirize kumvetsetsa zomwe zikuchitika, koma ndizosangalatsa kulingalira za zotsatira zachipatala zomwe tapeza pokhudzana ndi chidziwitso ndi maganizo," adatero Dr. Gonzales.


Nthawi yotumiza: 26-08-21